Saturday, August 9, 2008

Remembering the Anthrax Vaccine Controversy

Crossposted from our new home blog,They gave us a republic...


I remember the controvery over having to receive shots of the Anthrax vaccine--no one knew if it was causing serious health problems and members of the military were refusing to get the shots:

Military personnel, under the threat of court-martial, were refusing inoculations of an anthrax vaccine. The vaccine’s sole manufacturing plant was ordered to shut down. Researchers were turning up evidence possibly linking the vaccine to illnesses of soldiers during the Persian Gulf war of 1991.

It was hardly the thank you that Dr. Bruce E. Ivins expected for his years of labor to produce a vaccine that would protect military personnel from an anthrax attack by the Iraqi leader Saddam Hussein or some other adversary.

The criticism, which reached its peak in 2000 and early 2001, was clearly starting to get on Dr. Ivins’s nerves. “I think the **** is about to hit the fan ... big time,” he wrote in a July 2000 e-mail message about the inoculation program, according to a government affidavit. “It’s just a fine mess.”

This turmoil has now been cited by federal investigators as a key part of the reason they believe that Dr. Ivins sent out anthrax-laced letters in the fall of 2001 — as such an attack would, in a single stroke, have eliminated the skepticism and second guessing about the need for an anthrax vaccine.


They ran out before I was supposed to receive the shots--a series of several painful shots over an extended period of time--and I never got it. My wife received the shots, and told me she experienced a great deal of pain in her arm.


But it is true--there was turmoil. A handful of people were refusing to get it, touching off controversy. Well, not controversy. Mostly, disgust that there were people refusing to follow orders.

This was a fight the military wasn't going to lose, of course, and many were forced to get the shots (until they ran out, of course).

I don't know why they're continuing to use all of these different issues to pound Dr. Bruce Ivins, but this is essentially what was going on:

This turmoil has now been cited by federal investigators as a key part of the reason they believe that Dr. Ivins sent out anthrax-laced letters in the fall of 2001 — as such an attack would, in a single stroke, have eliminated the skepticism and second guessing about the need for an anthrax vaccine.

The investigators suggest that Dr. Ivins had been struggling with psychological problems, and was on medication and undergoing counseling after being overcome by what he described as paranoid, delusional thoughts. The trouble with the vaccine, they argue, may have been enough to set him off.


At that stage of his career, was he ready to risk everything and do something that just seems stupid--and that is, use weaponized Anthrax to prove what he was working on was vital and necessary? You have to assume he was willing to take steps that are unimaginable for someone working on a way to keep people safe from being killed by Anthrax. You have to be willing to suspend a lot of disbelief for that theory to work.

Dr. Ivins’s former colleagues reject that two-part theory, saying it is just one of many flaws in the evidence presented by the government in an unconvincing case.

There was a real threat, the former colleagues acknowledged, that the anthrax vaccine Dr. Ivins had worked on during that period, known as Anthrax Vaccine Absorbed or AVA, might be pulled from the market

Most troubling were problems at the Michigan manufacturing plant, which had been shut down in 1998 after the Food and Drug Administration uncovered serious flaws.

Dr. Ivins and other researchers, however, had been working on a more advanced alternative vaccine — considered safer and more effective — so there was no reason for such a rash act, his former colleagues say.

“There was a lot of consternation, a lot of pressure to rescue this thing,” said Jeffrey Adamovicz, one of Dr. Ivins’s fellow researchers at the time. “But if AVA failed, he had his next vaccine candidate. It was well on its way to what looked to be a very bright future.”

The vaccine controversy erupted in the late 1990s, after the Defense Department ordered the inoculation of all 2.4 million active duty and reserve troops, starting with those most likely to confront biological attacks in war zones, partly because Iraq had confirmed that it once had a large stockpile of anthrax that was destroyed after the first Persian Gulf war.

By 2000, more than 570,000 military personnel had complied with the order, and hundreds had filed an “adverse event report” after receiving the shots, citing reactions that included fatigue, dizziness and muscle pain, and more serious conditions like thyroid disorders and rhabdomyolysis, a muscle ailment.


It was scary, but there was nothing you could do about it. Once you join the military, be prepared to follow every stupid order. That's just how it is.

What the Justice Department has not produced is evidence documenting that Dr. Ivins’s frustrations motivated him to retaliate with the anthrax letters.

Gerard P. Andrews, another of Dr. Ivins’s former colleagues, said he knew that Dr. Ivins was frustrated, but that he doubted that Dr. Ivins would consider such a step.


Well, we lived with the controversy, and I've never regretted the fact that they ran out of the vaccine before I had to get it.
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